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Michelle Ammerman

Research Interests

RNA binding proteins

Gene regulation in Trypanosoma brucei

Medicinal properties of plant extracts

Anaerobic digestion and biogas production

 

Education

B.A. Biology, University of Texas at Austin, Austin, TX, 1999

PhD Biochemistry, University at Buffalo, Buffalo, NY, 2006

 

Experience

Assistant Professor,  Kettering University,  Flint,  MI,  2013 – present

Postdoctoral Associate,  University at Buffalo,  Buffalo,  NY  2006-2013

 

Research Activities

Medicinal Properties of Supercritical Fluid Extraction Products from Commonly Discarded Fruit Parts, Jonathan Wenzel, Lihua Wang, Cheryl Samaniego, Ali Zand, Kettering University, Flint, MI 2013-present

Analysis of anaerobic digestion and biogas production, Steve Nartker and Chad Antle, Bioworks Energy LLC, 2013-present

RNA binding proteins  in the protozoan parasite Trypanosoma brucei, 2006-present

 

Selected Publications

McAdams, N. M., Ammerman, M. L., Nanduri, J., Lott, K., Fisk, J. C., & Read, L. K. (2014). An arginine-glycine rich RNA binding protein impacts the abundance of specific mRNAs in the mitochondria of Trypanosoma brucei. Eukaryotic cell, EC-00232.

Nartker, S., Ammerman, M., Aurandt, J., Stogsdil, M., Hayden, O., & Antle, C. (2014). Increasing biogas production from sewage sludge anaerobic co-digestion process by adding crude glycerol from biodiesel industry. Waste Management, 34(12), 2567-2571.

Ammerman, M. L., Tomasello, D. L., Faktorová, D., Kafková, L., Hashimi, H., Lukeš, J., & Read, L. K. (2013). A Core MRB1 Complex Component Is Indispensable for RNA Editing in Insect and Human Infective Stages of Trypanosoma brucei. PloS one, 8(10), e78015.

Hashimi, H., Zimmer, S. L., Ammerman, M. L., Read, L. K., & Lukeš, J. (2013). Dual core processing: MRB1 is an emerging kinetoplast RNA editing complex. Trends in parasitology, 29(2), 91-99.

Kafková, L., Ammerman, M. L., Faktorová, D., Fisk, J. C., Zimmer, S. L., Sobotka, R., … & Hashimi, H. (2012). Functional characterization of two paralogs that are novel RNA binding proteins influencing mitochondrial transcripts of Trypanosoma brucei. RNA, 18(10), 1846-1861.

Ammerman, M.L., Downey, K.M., Hashimi, H., Fisk, J.C., Tomasello, D.L., Faktorova, D., Kafkova, L., King, T., Lukes, J., and Read, L.K. “Architecture of the trypanosome RNA editing accessory complex, MRB1.” (2012) Nucleic acids Res 40, 5637-5650.

Read, L. K., Zimmer, S. L., & Ammerman, M. L. (2011). Marked for Translation: Long A/U Tails as an Interface between Completion of RNA Editing and Ribosome Recruitment. Molecular cell, 42(1), 6-8.

Ammerman, M.L., Hashimi, H., Novotna, L., Cicova, Z., McEvoy, S.M., Lukes, J., and Read, L.K. (2011). MRB3010 is a core component of the MRB1 complex that facilitates an early step of the kinetoplastid RNA editing process. RNA 17, 865-877.

Ammerman, M. L., Presnyak, V., Fisk, J. C., Foda, B. M., & Read, L. K. (2010). TbRGG2 facilitates kinetoplastid RNA editing initiation and progression past intrinsic pause sites. RNA, 16(11), 2239–2251.

Fisk, J.C., Presnyak, V., Ammerman, M.L., and Read, L.K. (2009). Distinct and overlapping functions of MRP1/2 and RBP16 in mitochondrial RNA metabolism. Mol Cell Biol 29, 5214-5225.

Khaperskyy, D.A., Ammerman, M.L., Majovski, R.C., and Ponticelli, A.S. (2008). Functions of Saccharomyces cerevisiae TFIIF during transcription start site utilization. Mol Cell Biol 28, 3757-3766.

Fisk, J.C., Ammerman, M.L., Presnyak, V., and Read, L.K. (2008). TbRGG2, an essential RNA editing accessory factor in two Trypanosoma brucei life cycle stages. J Biol Chem 283, 23016-23025.

Ammerman, M. L., Fisk, J. C., & Read, L. K. (2008). gRNA/pre-mRNA annealing and RNA chaperone activities of RBP16. RNA , 6, 1069–1080.

Fish, R. N., Ammerman, M. L., Davie, J. K., Lu, B. F., Pham, C., Howe, L., Ponticelli, A. S., & Kane, C. M. (2006). Genetic interactions between TFIIF and TFIIS. Genetics, 4, 1871–1884.

Ghazy, M. A., Brodie, S. A., Ammerman, M. L., Ziegler, L. M., & Ponticelli, A. S. (2004). Amino acid substitutions in yeast TFIIF confer upstream shifts in transcription initiation and altered interaction with RNA polymerase II. Molecular and cellular biology, 24, 10975–10985.

Ziegler, L. M., Khaperskyy, D. A., Ammerman, M. L., & Ponticelli, A. S. (2003). Yeast RNA polymerase II lacking the Rpb9 subunit is impaired for interaction with transcription factor IIF. The Journal of biological chemistry, 49, 48950–48956. 

 

Contact Information

Email: mammerman@kettering.edu

Phone:  (810) 249-4381

Office:  2212G AB